Industry applications
One extraction technology, numerous industry applications
Our proprietary technology enables superior extraction from various natural sources, with potential applications in:
• Cosmetics
• Animal Health
• Human Health
• Plant Healt
• Food
What is exactly our technology?
WO2020169425 – LIQUID PROPOLIS EXTRACT, ITS FORMULATION AND USE THEREOF
• First pharmaceutically standardized non-alcoholic propolis extract
• Suitable for large-scale production
• The extract is characterized by standardized content of p-coumaric acid (1), trans-ferulic acid (2), caffeic acid (3), and CAPE (4).
• It is used as an active ingredient in manufacturing pharmaceutical, cosmetic, veterinary, agrochemical, or functional food products
• No use of solid and aggressive solvents like alcohol
• Chemoselective extraction of bioactive molecules with the help of added emulsifier (lecithin)
The problem that is solved
• a non-alcoholic liquid propolis extract, which would be characterized by high and standardized content of phenolic propolis acids, para-coumaric acid (1), trans-ferulic acid (2), caffeic acid (3) and 2-phenylethyl ester of caffeic acid, 2- phenethyl 3 , 4-dihydroxy- trans-cinnamate (4; CAPE), for which several beneficial pharmacological activities are known, on both human and animal organisms;
• the process for its production;
• use for the production of pharmaceutical, cosmetic, veterinary, agrochemical, or food products with known, standardized content of propolis active substances 1-4; and especially,
• a pharmaceutical composition based on the mentioned propolis extract, which would be effective in the treatment of inflammatory and infective diseases, as well as diseases and conditions where the antioxidative, anti-inflammatory, and immunomodulatory activity of particular propolis active substances, play an important role in the etiology of their incidence, as suggested by certain references in the state of the art.
Our products are derived from bee products via a standardized extraction & purification process
RAW PRODUCTS
POLLEN
INTERMEDIATE PRODUCT
POLLEN
RAW PRODUCTS
POLLEN
INTERMEDIATE PRODUCT
POLLEN
RAW PRODUCTS
PROPOLIS
INTERMEDIATE PRODUCT
PROPOLIS
RAW PRODUCTS
PROPOLIS
INTERMEDIATE PRODUCT
PROPOLIS
ApiPhenocomplex
Key take-aways:
- Liquid extract with standardized content of bioactive compounds
- Broad spectrum antimicrobial efficacy
- Efficacy against multidrug resistant pathogens & biofilm
- Potent antioxidant effect
- Alternative to antibiotics with minimum risk of resistance development
- Potential of translation to human medicine
ApiPhenocomplex
Key take-aways:
– Liquid extract with standardized content of bioactive compounds
– Broad spectrum antimicrobial efficacy
– Efficacy against multidrug resistant pathogens & biofilm
– Potent antioxidant effect
– Alternative to antibiotics with minimum risk of resistance development
– Potential of translation to human medicine
collection of raw material – physical separation – chemical purification – quality control
Cosmetics
Natural antioxidant to prevent skin damage & ageing
• Our extracts can be easily integrated into various cosmetic formulations: creams, gels, ointments, and lotions.
• Easy mixing with all kinds of bases and solvents
• A natural preservative and antioxidant for increased product stability
• Proven to be non-toxic on keratinocytes
Skin care
Natural antioxidant to prevent skin damage & ageing
Potential applications:
• Anti-age cosmetics: as an antioxidant and regenerative principle
• For dry and damaged skin: as an anti-inflammatory
• Anti-acne formulations
• For hair loss: stimulates the hair growth by inducing hair keratinocyte proliferation
• Proven to be non-toxic on keratinocytes
Human health
Natural antimicrobial and anti-inflammatory agent
• Wound healing
• Antimicrobial Urinary Catheter Coating Agent
• Topical anti-inflammatory agent:
• Gingivitis/periodontitis
• Sore throat
Wound healing
Antimicrobial and regenerative activity
• Our standardized propolis extract (SPE) can be integrated into various dosage forms for burn & wound care:
• Wound dressings: hydrogels, hydrocolloids, foams, films, alginates, composites
• Wound ointments, creams, and gels
• Wound wash
Wound healing
In vitro assay
The scratch test assay:
• On the left, the first day after the damage. On the right, the second day after application of our 1% extract
Wound healing
In vivo
• Numerous examples from clinics, like the dog with severe burns
• The period between the left and the right picture is 3-4 weeks
Animal health
Fighting antimicrobial resistance, improving animal welfare
• Mastitis
• Wound healing
• Periodontitis/Gingivitis
• ApiWater – cleaner water, better growth performance
• Feed supplementation – liquid and powder formulations of honey bee-based products
Wound healing
Clinical evidence
• Our extract was used in wound healing case studies in animals. It improved the impaired healing of wounds in horses and many companion animals.
• It was tested for tolerance and safety on sensitive cow udder tissue.
• MTT tests showed that it is not cytotoxic
On the left: wound on the horse’s front leg after 10 days of unsuccessful treatment with the combination of silver nitrate, iodine, and antibiotic. On the right: wound 72 h after propolis extract application (With the courtesy of Prof. Nikica Prvanović Babić, Ph.D., DVM)
On the left: a dog with second-degree burns from the fire. On the right: after treatment with our extract ointment.
On the left: hot spot on dog paw. On the right: after treatment with our extract ointment
Plant health
For safe food and a healthy environment
• Our extracts can be used for crop protection in organic agriculture
• Alternative to pesticides
• Added value to the final organic product
• Synergy with other crop protection agents
Food
Natural food preservative & antioxidant
Potential applications:
• As food & beverage antioxidant with numerous health benefits
• Functional food additive: improved glycemic control, energy boosting adaptogen)
• Natural additive for food biodegradable packaging: superior antioxidant and antimicrobial food protection
More than one extract
Standardized natural product with superb quality
• Our technology enables us to extract bioactive compounds from natural sources without aggressive solvents and extensive energy consumption
• Our production is environmentally friendly and sustainable
• We invest in R&D of natural products from various sources
Contact us
We are working with strategic partners, investors and scientists all around the world!
